Helix pomatia agglutinin binding in human tumour cell lines: correlation with pulmonary metastases in nude mice
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چکیده
منابع مشابه
lectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin
altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. the aim of the present study was to identify the n-acetylgalactosamine (galnac) containing glycoconjugates in cancer cells in a...
متن کاملLectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin.
Altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. Lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. The aim of the present study was to identify the N-acetylgalactosamine (GalNac) containing glycoconjugates in cancer cells in a...
متن کاملExpression of calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice.
Since our aim was to isolate and identify new progression markers of human cutaneous melanoma, we applied the differential hybridization technique, in which we compared the gene expression in two subsequent stages of this progression. Tumors in nude mice arising after transplantation and serial passage in vivo of either the horizontally and early vertically growing part or the advanced vertical...
متن کاملBiochemical and Structural Analysis of Helix Pomatia Agglutinin (hpa): a Hexameric Lectin with a Novel Fold*
AGGLUTININ (HPA): A HEXAMERIC LECTIN WITH A NOVEL FOLD* Jean-Frederic Sanchez, Julien Lescar, Valérie Chazalet, Aymeric Audfray, Jean Gagnon, Richard Alvarez, Christelle Breton, Anne Imberty & Edward P. Mitchell From Centre de Recherches sur les Macromolécules Végétales, CNRS (affiliated with Université Joseph Fourier), Grenoble, France, School of Biological Sciences, Nanyang Technological Univ...
متن کاملBiochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold.
Helix pomatia agglutinin (HPA) is a N-acetylgalactosamine (GalNAc) binding lectin found in the albumen gland of the roman snail. As a constituent of perivitelline fluid, HPA protects fertilized eggs from bacteria and is part of the innate immunity system of the snail. The peptide sequence deduced from gene cloning demonstrates that HPA belongs to a family of carbohydrate-binding proteins recent...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1994
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1994.200